Thursday, 25 June 2020 18:57

The daily use of UGO BASILE TREADMILL improves motor deficits and dopaminergic functions in a Rat hemi-Parkinson’s model! A recent publication

This is what Professor Barry J. Hoffer (Clevland) & Professor Yuan-Hao Chen et Al. from the National Defense Medical Center Taipei, Taiwan (Department of Neurological Surgery) have concluded in a publication in NATURE SCIENTIFIC REPORTS.

47302 d                 47750 leaflet

Using UGO BASILE TREADMILL and ROTAROD They designed the research and performed the experiment which demonstrate the positive effects of a daily exercise session, on kinematics and motor coordination, cortico-striatal plasticity and reduction of DA receptor supersensitivity. 


“Parkinson’s disease is second most common neuron degenerative disease, and is characterized by symptoms related to progressive dopamine neuron loss within the substantia nigra pars compacta1. In addition to dopaminergic
neuron loss, other neurotransmitter systems have been indicated to be involved in the disease; thus PD is now been thought to be multisystem disorder. Gait disturbances have been shown in Parkinson’s disease (PD)4. In addition to the typical motor deficits in Parkinson’s disease including bradykinesia, rigidity, resting tremor and postural instability, increasing data has indicated that incoordination and temporal asymmetry results in disturbances of internal gait rhythm and walking speed in PD subjects5. The cadence and double stand time also increases. Moreover, the deficits in spatial indices of gait seen in PD patients and animals includes short steps, decreased stride length and freezing7. These abnormalities in gait increased as the disease progressed. Exercise is currently an important treatment for PD.”

Read the complete Work at the following link: Y.H Chen et alia: SCIENTIFIC REPORTS (2018) 8:3973 DOI:10.1038/s41598-018-22462-y

Scientific Report 2018 8 3973

Last modified on Thursday, 25 June 2020 18:57