NEW:
- Bright touch screen for enhanced usability and intuitive menus
- Automatic tail flick detection or via foot pedal, for the best repeatibility and human sensitivity
NEW:
- Automatic and manual measurement of the paw wihdrawal latency time and energy
- Touch screen for complete management of settings, testing, result view and download
NEW:
- Maximum Force is 100g (formerly 50g) with optional manual scoring
- Touching force and touching pause adjustable parameters (to control the stimulus approaching phase)
- TTL I/O for trigger input and output and embedded hard disk so that the USB key is used for data export/import only
Le Gradient thermique annulaire est un nouveau test automatisé et intégré qui permet d’analyser la préférence thermique spontanée chez la souris sans biais et avec une double occurence, selon la méthode décrite par Zimmermann:
“Comprehensive thermal preference phenotyping in mice using a novel automated circular gradient assay”.
Quelles sont ls principales innovations attachées au TGR?
Il y en a beaucoup, mais le point le le plus important est la sensibilité dérivant de la capacité à disséquer le comportement thermique du comportement exploratoire non thermique, en plus de l'automatisation et de la minimisation des biais experimentaux du test..
Regardez la vidéo suivante qui illustre une exploration typique du gradient annulaire
Contactez nous pour de plus amples détails:
Chun Yang, Xi Fang et ses collègues à Tongji Medical College, Wuhan, China, Soochow University, Changzhou, Chine, et Chiba University, Chiba, Japon, Ont récemment publié des résulats de recherche intéréssants dans le journal TRANSLATIONAL PSYCHIATRY, à propos du rôle du microbiote intestinale dans les phénotypes de type anhédonique sur des rongeurs atteints de douleurs neuropathiques.
Les résultats de tests à l'allodynie mécanique ont été obtenu avec l'instrument Von Frey électronique de UGO BASILE e-vf Electronic VonFrey eVF.
Extrait
“Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which is a core symptom of depression. Accumulating studies suggest that gut microbiota may play a role in depression via gut–microbiota–brain axis. However, it is unknown whether gut microbiota plays a role in neuropathic pain-associated anhedonia. Here, we used a rat model of spared nerve injury (SNI). Hierarchical cluster analysis of sucrose preference test (SPT) results was used to classify the SNI rats with or without anhedonia-like phenotype. The 16S ribosomal RNA sequencing analysis showed abnormal composition of gut microbiota in the anhedonia susceptible compared to sham-operated rats and resilient rats. Furthermore, antibiotics-treated mice showed pain as well as depression-like and anhedonia-like phenotypes, suggesting a role of gut microbiota in these abnormal behaviors. Transplantation of fecal microbiota from anhedonia susceptible rats into antibiotics-treated pseudo-germ-free mice significantly exaggerated pain and depression-like phenotypes, including anhedonia. In contrast, transplantation of fecal microbiota from resilient rats into antibiotics-treated pseudo-germ-free mice significantly improved pain and depression-like phenotypes, including anhedonia. In conclusion, this study suggests that abnormal composition of gut microbiota may contribute to anhedonia susceptibility post SNI surgery, and that gut microbiota also plays a role in the pain as well as depression-like phenotypes. Interestingly, fecal microbiota transplantation from SNI rats with or without anhedonia can alter pain, depression-like and anhedonia-like phenotypes in the pseudo-germ-free mice. Therefore, it is likely that gut microbiota plays a key role in the pain as well as depression-like phenotypes including anhedonia in rodents with neuropathic pain.”
Accés à l apublication complète ici: https://www.nature.com/articles/s41398-019-0379-8
Voici un poster présenté à Measuring Behavior 2018 Manchester qui présente un comparatif des résultats obtenus avec deux marques différentes de rotarod
Notre Test de conditionnement à la peur est apprécié et utilisé par de nombreux chercheurs, en France et travers le monde pour ses performances et sa finesse de détection. NOUS AVONS TRAVAILLE et L'AVONS RENDU ENCORE PLUS PERFORMANT !
Notre département R & D et notre usine ont la capacité et la volonté de personnaliser les instruments existants pour mieux répondre à vos besoins expérimentaux, ou de créer de nouveaux instruments à partir de rien, en fonction des besoins de l'utilisateur.
Demandez des détails!
Download our latest catalogue illustrating the range of UB devices
Innovation is the motor which drives us at Ugo Basile
for easy upgrade of all UB Analgesy-Meters to digital reading
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