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47500/50 - Learned Helplessness
At the core of the Learned Helplessness system is a dark isolation cube, in which the subject is placed, and a controller. The chamber is outfitted with an electrified grid floor, and connected to the controller which consists of a shock generator, as well as a timer that incorporates timing and randomizing. Shocks can be randomized on the basis of duration as well as by interval between shock events.
At the core of the Learned Helplessness system is a dark isolation cube, in which the subject is placed, and a controller. The chamber is outfitted with an electrified grid floor, and connected to the controller which consists of a shock generator, as well as a timer that incorporates timing and randomizing. Shocks can be randomized on the basis of duration as well as by interval between shock events.
Also, more complex trains of shocks can be programmed. This system is expandable, for stimulation of up to 4 animals simultaneously. Mouse or Rat cages are available. When rodents are exposed to inescapable and unpredictable stress, such as forced swim or inescapable footshock, they often develop deficits in memory and learning tasks (e.g. Active Avoidance), and often show also analgesic reactions (S.I.A. Stress-Induced Analgesia).
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Features and Benefits
Specifications
Bibliography
| FEATURE |
BENEFIT |
| Fully randomizable shock patterns |
Randomization involves shock duration, interval, train |
| Genral purpose triggerable shockers |
Can be used also for Fear Conditioning |
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| Mouse cage dimensions: |
17 x17 x 20 (h) cm |
| Rat cage dimensions: |
22 x 22 x 20 (h) cm |
| Shocker constant current: |
from 0,1 to 2.9 mA in 0,1 mA steps |
| Shocker manual or external operation: |
via 5V TTL signals |
| Timer: |
connects to up to 4 cages |
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- Borsini & Cesana 2001. "Mechanisms of action of flibanserim in the learned helplessness in rats". European Journal of Pharmacology 433: 81-89.
- Grau et al. 1981. "Long-term analgesia and activation of the opiate system". Science Vol. 213, 1409-1411.
- Guilherme dos Santos et al. 2008. "Antidepressive like effects of electroacupuncture in rats". Phisiology & Behaviour 93: 155-159.
- Kademian et al. 2005. " Biphasic effects of adrenal steroid on learned helplessness behavior by inescapable shock". Neuropsychopharmacology 30: 58-66.