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37370 - Plantar Test (Hargreaves Apparatus)
The new Plantar Test Instrument (Hargreave’s Method) measures response to infrared heat stimulus.
Focus the infrared source below the Plantar surface and with the press of a button … latency to paw withdrawal and infrared intensity are recorded automatically (i.e. no manual scoring!).
The new Plantar Test Instrument (Hargreave’s Method) measures response to infrared heat stimulus.
Focus the infrared source below the Plantar surface and with the press of a button … latency to paw withdrawal and infrared intensity are recorded automatically (i.e. no manual scoring!).
Classically the measurement of acute nociceptive thermal threshold in laboratory animals has primarily relied upon the tail flick and hot plate methods. Although both methods are still used frequently in pharmacological studies, they are not without limitation. In addition, neither method has been extended to investigating behavioural responses to hyperalgesia.
The Plantar Test represents a remarkable advance in methodology, as it combines the best features of all other methods of measuring pain sensitivity. Unique to the Plantar Test, the animal is unrestrained during experiments. Moreover, time latency is recorded automatically by a fiber optic sensor, without having to rely on the experimenter observation of the animal behaviour.
Data appear on the front panel and may be exported to a memory stick, or to computer via USB; software is included.
Features and Benefits
Specifications
Accessories
Bibliography
| FEATURE |
BENEFIT |
| Paw withdrawal is scored automatically, by a fiber optic |
Precise score with no human variability |
| USB memory key and software are included |
Works as a stand-alone or connected to the PC |
| Cages with compartments of adjustable area (up to 12 mice) |
Optimize for rats or mice and increase throughput |
| |
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| Commands: |
via “soft keys” |
|
Data Portability: |
via memory key provided |
| Read-out : |
multifunction graphic display |
|
Power Requirement: |
universal mains 85-264 VAC, 50-60Hz |
| Print-out: |
by optional thermal mini-printer |
|
Operating Temperature: |
15° to 30° C |
| Starting: |
via keys on the I.R. Vessel. Additional key on the controller |
|
Sound Level: |
< 70 dB |
| I.R. Intensity: |
adjustable in the interval 01-99 (in one-digit steps) |
|
Calibration |
via appropriate I.R. Radiometer |
| Reaction Time: |
displayed on the graphic display, in 0.1s steps |
|
Connection to PC |
through DELTA 9-pin connector. See paragraph 3.5 |
| I.R. Bulb: |
Halogen "Bellaphot", Mod. 64607 OSRAM, 8V-50W |
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| Physical Dimensions |
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| Dimensions (assembled): |
85 x 40 x 35 cm |
| Weight: |
13.00 Kg |
| Shipping Weight: |
27.50 Kg approx |
| Packing dimensions: |
109 x 53 x 55 cm |
Method Paper:
- D.C. Yeomans & H.K. Proudfit: “Characterization of the Foot Withdrawal Response to Noxious Radiant Heat in the Rat” Pain 59: 85-97, 1994.
- K.M. Hargreaves, R. Dubner, F. Brown, C. Flores and J. Joris: "A New and Sensitive Method for Measuring Thermal Nociception in Cutaneous Hyperalgesia." Pain 32: 77-88, 1988.
Papers mentioning UB model:
- D. Piomelli et alia:” Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism”. Nature NSC, 2010
- Mark J. Field et alia: “Detection of Static and Dynamic Components of Mechanical Allodynia in Rat Models of Neuropathic Pain: Are They Signalled by Distinct Primary Sensory Neurones?” Pain 83: 303-311, 1999
- Fred Lembeck: “Epibatine: High Potency and Broad Spectrum Activity on Neuronal and Neuromuscular Nicotinic Acetylcholine Receptors” Naunyn-Schmiedeberg’s Arch. Pharmacol. 359:378-385, 1999
- Hartmut Buerkle et alia: “Experimental Arthritis in the Rat Does Not Alter the Analgesic Potency of Intrathecal or Intraarticular Morphine” Anesth. Analg. 89: 403-408, 1999.
